Celiac Disease DNA Test
Valued at: $390.80
Our Price: $320.00

  Description   Test Includes  

CELIAC DISEASE DNA TEST


Celiac Disease is a chronic autoimmune disorder caused by the ingestion of gluten, which causes inflammation of the small intestine and leads to malabsorption. Celiac disease affects approximately 1:120-1:300 individuals in the European and North American populations and is considered to be is one of the most common and under-diagnosed diseases today. A Celiac Disease DNA test should be taken if the disease runs in the family, or if you've had undiagnosable gastro-intestinal problems.

A person with celiac disease commonly suffers from gastrointestinal problems. Celiac disease is caused when digested wheat produces too much of a certain protein, which causes the bloodstream to be flooded with toxins from the small intestine. The bloodstream sees these toxins as an infection, and promptly attacks the lining of the small intestine. This autoimmune response leads to nutritional deficiencies. A Celiac Disease DNA test from HealthCheckUSA is easy, quick, and reliable.

On the genetic side, Celiac disease is due to the interactions of several HLA and non-HLA genes with gluten. It is strongly associated with the human leukocyte antigen (HLA) molecule DQ2 (encoded by alleles DQA1*0501 or *0505 plus DQB1*0201 or *0202) and DQ8 (encoded in part by DQB1*0302). More than 90% of patients with a positive Celiac Disease DNA test carry DQ2 while most of the remaining 10% of cases carry DQ8. Early detection through a Celiac Disease DNA test and subsequent elimination of gluten from the diet is essential in aiding disease prevention and treatment. Antiendomysial and tissue transglutaminase antibody test results can be equivocal depending upon diet adherence and stage of disease. However, results from a Celiac Disease DNA test are always reliable and need only be performed once in a lifetime.

A Celiac Disease DNA test from HealthCheckUSA includes:

* PCR analysis for DQ2 alleles DQA1*0501, DQA1*0505, and DQB1*0201/*0202 and DQ8 allele DQB1*0302.
*Detailed Reports with genetic interpretation, recommendations, and education.
* Free genetic counseling for physicians, patients, and families through our partner company Kimball Genetics.

Indications for Celiac Disease DNA Testing


• Clinical diagnosis of celiac disease
• Negative or equivocal antibody results (antiendomysial, tissue transglutaminase, or antigliadin) or intestinal biopsy results in an individual with symptoms of celiac disease
• Relatives of individuals with celiac disease
• Individuals with iron-deficient anemia
• Individuals with dermatitis herpetiformis
• Adults with diarrhea, abdominal pain and distention, recurrent aphthous stomatitis (cold sores), osteoporosis, infertility, multiple miscarriages, anxiety, and/or depression
• Children with abdominal pain, diarrhea, abdominal distention, failure to thrive, short stature, delayed puberty, irritability, attention-deficit disorder, and/or poor school performance.